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Journals / Turkish Journal of Medical Sciences / 2020 / Cilt: 50 - Sayı: 4

Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR

Mustafa NİSARİ
Recep ERÖZ
Pages
1076–1081
Publication Date
2022-11-05
DOI
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Also, there were significant differences between control and capsaicin (50uµ) (P = 0.001), between control and capsaicin(75uµ) (P = 0.000), between capsaicin (25uµ) and capsaicin (50uµ) (P = 0.000) and between capsaicin (25uµ) and capsaicin (75uµ) (P= 0.000) for mean AgNOR number.Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations areimportant for the most reliable treatment.

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Objective & Hypothesis:Background/aim: To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinomaderivate from colon cancer (Caco-2 cell).Materials and methods: In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as controland different capsaicin exposed doses (25uµ, 50uµ, and 75uµ).
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Key Findings & Data:Mean AgNOR number and total AgNOR area/nuclear area (TAA/NA)were calculated.Results: A significant differences were detected between control and capsaicin (50uµ) (P = 0.001), between control and capsaicin (75uµ)(P = 0.000), between capsaicin (25uµ) and capsaicin (50uµ) (P = 0.001) and between capsaicin (25uµ) and capsaicin (75uµ) (P = 0.000)for TAA/NA.
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Conclusion & Impact:Also, there were significant differences between control and capsaicin (50uµ) (P = 0.001), between control and capsaicin(75uµ) (P = 0.000), between capsaicin (25uµ) and capsaicin (50uµ) (P = 0.000) and between capsaicin (25uµ) and capsaicin (75uµ) (P= 0.000) for mean AgNOR number.Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations areimportant for the most reliable treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinomaderivate from colon cancer (Caco-2 cell).Materials and methods: In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as controland different capsaicin exposed doses (25uµ, 50uµ, and 75uµ). Mean AgNOR number and total AgNOR area/nuclear area (TAA/NA)were calculated.Results: A significant differences were detected between control and capsaicin (50uµ) (P = 0.001), between control and capsaicin (75uµ)(P = 0.000), between capsaicin (25uµ) and capsaicin (50uµ) (P = 0.001) and between capsaicin (25uµ) and capsaicin (75uµ) (P = 0.000)for TAA/NA. Also, there were significant differences between control and capsaicin (50uµ) (P = 0.001), between control and capsaicin(75uµ) (P = 0.000), between capsaicin (25uµ) and capsaicin (50uµ) (P = 0.000) and between capsaicin (25uµ) and capsaicin (75uµ) (P= 0.000) for mean AgNOR number.Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations areimportant for the most reliable treatment.

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Cite This Article

NİSARİ, M., ERÖZ, R. (2022). Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR. Turkish Journal of Medical Sciences, Cilt: 50 - Sayı: 4, 1076–1081. https://ajindex.com/articles/610055

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