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Journals / Turkish Journal of Medical Sciences / 2020 / Cilt: 50 - Sayı: 4

Thiol/disulphide homeostasis in intensive care unit patients with sepsis and septic shock

Hamit YILDIZ
Pages
811–816
Publication Date
2020-08-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Understanding the role of thiol/ disulphide homeostasis in sepsis and septic shock may provide different therapeutic intervention strategies for patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: Sepsis is a condition caused by infection followed by unregulated inflammatory response which may lead to organ dysfunction.
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Key Findings & Data:Material and methods: A total of 113 patients septic shock 53 and sepsis 60 and 60 healthy control subjects have been enrolled in this study from the period February 2018 to 2019.
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Conclusion & Impact:Understanding the role of thiol/ disulphide homeostasis in sepsis and septic shock may provide different therapeutic intervention strategies for patients.
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Oxidative stress · antioxidant level · tissue damage

Abstract

Background/aim: Sepsis is a condition caused by infection followed by unregulated inflammatory response which may lead to organ dysfunction. The aim of this study is to be the first in the literature and it has been designed to show the thiol/disulphide changes in patients with sepsis and septic shock and their correlation with acute phase reactants. Material and methods: A total of 113 patients septic shock 53 and sepsis 60 and 60 healthy control subjects have been enrolled in this study from the period February 2018 to 2019. The patients were divided in 2 groups: nonsurvivors 74 and survivors 39 . The investigation includes measurements of native thiol, total thiol, dynamic disulphide bond, oxidized thiol ratio, reduced thiol ratio and thiol oxidation reduction ratio, erythrocyte sedimentation rate, C-reactive protein, and procalcitonin. Results: The findings of this study suggest that changes in thiol levels play a role in the pathogenesis of patients with sepsis and septic shock. Conclusions: Thiol/disulphide homeostasis is impaired in patients with sepsis and septic shock. Understanding the role of thiol/ disulphide homeostasis in sepsis and septic shock may provide different therapeutic intervention strategies for patients.

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Cite This Article

YILDIZ, H. (2020). Thiol/disulphide homeostasis in intensive care unit patients with sepsis and septic shock. Turkish Journal of Medical Sciences, Cilt: 50 - Sayı: 4, 811–816. https://ajindex.com/articles/113164

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