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Journals / İstanbul Tıp Fakültesi Dergisi / 2026 / Cilt: 89 Sayı: 2

MANAGEMENT OF THE VEIN OF GALEN ANEURYSMAL MALFORMATION CASES PRESENTING IN THE NEONATAL PERIOD

Sanubar Nazarli(İSTANBUL AYDIN ÜNİVERSİTESİ)0000-0002-1260-929X
Cafer Ikbal Gulsever(HAKKARI UNIVERSITY)0000-0002-9246-1378
Duran Şahin(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, İSTANBUL TIP PR.)0000-0003-2703-5687
Nahid Rustamov(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, İSTANBUL TIP PR.)0000-0002-5533-4353
Edanur Karapınar(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, İSTANBUL TIP PR.)0000-0002-5826-2041
Mehmet Barburoğlu(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, İSTANBUL TIP PR.)0000-0002-8715-1893
Serra Sencer(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, İSTANBUL TIP PR.)0000-0002-3942-093X
Burcu Göker(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL ŞİŞLİ HAMİDİYE ETFAL SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-6084-8690
Aydın Aydoseli(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, İSTANBUL TIP PR.)0000-0002-4695-8295
Pages
97–103
Publication Date
2026-05-13
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Early diagnosis, multidisciplinary management, and long-term follow-up are essential for optimizing survival and neurological outcomes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Vein of Galen aneurysmal malformations (VGAM) are rare congenital vascular anomalies with challenging management, especially in neonates with severe hemodynamic compromise.
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Key Findings & Data:Materials and Methods: We retrospectively analysed 14 patients diagnosed antenatally or symptomatic within 28 days, managed between 2005 and 2025.
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Conclusion & Impact:Early diagnosis, multidisciplinary management, and long-term follow-up are essential for optimizing survival and neurological outcomes.
🔬Design:Araştırma Makalesi
📍Scope:2005 Verileri
⚙️Variables:Vein of Galen malformation · Neonate · Endovascular treatment

Abstract

Objective: Vein of Galen aneurysmal malformations (VGAM) are rare congenital vascular anomalies with challenging management, especially in neonates with severe hemodynamic compromise. This study evaluated outcomes of neonatal VGAM treated with endovascular embolization at a single center. Materials and Methods: We retrospectively analysed 14 patients diagnosed antenatally or symptomatic within 28 days, managed between 2005 and 2025. Data included demographics, clinical and cardiac status, imaging, Bicêtre scores, treatment, and outcomes. Per protocol, embolization followed cardiopulmonary stabilization and could occur beyond the neonatal period. Results: Of the 14 neonates, 12 (85.7%) underwent embolization, while two (14.3%) died before intervention due to poor general condition. The mean gestational age was 38.8±1.0 weeks, and the mean birth weight was 3,283±292 g. The majority of the cases (66.7%) were classified as mixed-type VGAM. The mean Bicêtre score was 11.0±3.9. Embolization was performed at a mean of 176±149 postnatal days, requiring an average of 2.1 sessions per patient. Pulmonary hypertension and cardiomegaly were the most frequent cardiac findings (75% and 58.3%, respectively). The embolic agents included were n-butyl cyanoacrylate (NBCA) and ethylene vinyl alcohol copolymer (EVA). The mortality rate among embolized patients was 33.3%. Survivors exhibited normal neurodevelopment in 75% of the cases. Conclusion: Endovascular embolization is a viable strategy for VGAM cases presenting in the neonatal period, although mortality remains substantial in patients with severe cardiac compromise. Early diagnosis, multidisciplinary management, and long-term follow-up are essential for optimizing survival and neurological outcomes.

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Cite This Article

Nazarli, S., Gulsever, C. I., Şahin, D., Rustamov, N., Karapınar, E., Barburoğlu, M., Sencer, S., Göker, B., Aydoseli, A. (2026). MANAGEMENT OF THE VEIN OF GALEN ANEURYSMAL MALFORMATION CASES PRESENTING IN THE NEONATAL PERIOD. İstanbul Tıp Fakültesi Dergisi, Cilt: 89 Sayı: 2, 97–103. https://doi.org/10.26650/IUITFD.1684714

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