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Journals / European Journal of Biology / 2023 / Volume: 82 Issue: 2

Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac

Mehmet Ali Gül(Amasya University, Faculty of Medicine, Department of Medical Biochemistry)0000-0002-5849-0116
Fatma Betül Özgeriş(Ataturk University, Faculty of Healthy Sciences, Department of Nutrition and Dietetics)0000-0002-4568-5782
Nezahat Kurt(Erzincan Binali Yildirim University, Faculty of Medicine, Department of Medical Biochemistry)0000-0002-1685-5332
Burcu Volkan(Marmara University, Faculty of Medicine, Department of Pediatric Gastroenterology)0000-0002-0528-3826
Ali İşlek(Ataturk University, Faculty of Medicine, Department of Pediatric Gastroenterology)0000-0001-6172-7797
Atilla Çayır(Erzurum Regional Training and Research Hospital, Department of Pediatric Pediatric Endocrinology)0000-0001-9776-555X
Pages
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Publication Date
2023-12-21
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

While PON-1 values are significantly lower in newly diagnosed celiacs, it can be said that they reach normal values with adherence to a gluten-free diet.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Celiac disease (CD) is an inflammatory condition of the small intestine triggered by the consumption of gluten.
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Key Findings & Data:It was aimed to evaluate the effect of a gluten-free diet on serum total glutathione (tGSH) level, superoxide dismutase (SOD), myeloperoxida (MPO), paroxanase (PON-1) and aryl esterase (ARE) activity in patients with celiac disease, an autoimmune disease.
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Conclusion & Impact:While PON-1 values are significantly lower in newly diagnosed celiacs, it can be said that they reach normal values with adherence to a gluten-free diet.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Antioxidant · Celiac · Gluten-free Diet

Abstract

Objective: Celiac disease (CD) is an inflammatory condition of the small intestine triggered by the consumption of gluten. A strict gluten-free diet (GFD) is the only treatment that can eliminate CD complications. It was aimed to evaluate the effect of a gluten-free diet on serum total glutathione (tGSH) level, superoxide dismutase (SOD), myeloperoxida (MPO), paroxanase (PON-1) and aryl esterase (ARE) activity in patients with celiac disease, an autoimmune disease. Materials and Methods: The study was conducted with 68 participants, 39 of whom were celiac and 29 were healthy. Two groups were formed in patients with celiac disease as newly diagnosed and previously diagnosed and following a gluten-free diet. Blood samples were taken from all participants and tGSH, SOD, MPO, PON-1, and ARE measurements were made spectrophotometrically from serum samples. Results: While no significant change was observed in tGSH, SOD, and ARE levels, MPO activity was observed to be significantly lower in celiac patients compared to healthy controls, while this decrease was found to be higher in the newly diagnosed group. While PON-1 activity was significantly lower in newly diagnosed patients compared to the control group, it was higher in the gluten-compatible diet group. Conclusion: Low MPO values in celiac patients may be insufficient to function by creating oxidative stress in inflammation. While PON-1 values are significantly lower in newly diagnosed celiacs, it can be said that they reach normal values with adherence to a gluten-free diet.

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Cite This Article

Gül, M. A., Özgeriş, F. B., Kurt, N., Volkan, B., İşlek, A., Çayır, A. (2023). Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac. European Journal of Biology, Volume: 82 Issue: 2. https://doi.org/10.26650/EurJBiol.2023.1307239

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