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Journals / European Journal of Biology / 2026 / Volume: 85 Issue: 2

Panax ginseng Ameliorates Bisphenol A-Induced Liver and Kidney Damage in Rats

Najiullah Fazalyar(MARMARA UNIVERSITY)0009-0009-0725-8702
Sümeyye Karaoğlu Yılmaz(FENERBAHCE UNIVERSITY)0000-0001-5529-7380
Elif Tufan(OKAN UNIVERSITY)0000-0003-0684-3693
Aleyna Muhan(MARMARA UNIVERSITY)0000-0002-1958-4814
Esin Ak(MARMARA UNIVERSITY)0000-0002-3467-7808
Göksel Şener(FENERBAHCE UNIVERSITY)0000-0001-7444-6193
Tuğba Tunalı-Akbay(MARMARA UNIVERSITY)0000-0002-2091-9298
Pages
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Publication Date
2026-06-12
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Considering the widespread environmental exposure to BPA, PxG may represent a promising therapeutic agent for preventing BPA- induced hepatic and renal injury.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective : Bisphenol A (BPA) is an industrial chemical that disrupts the endocrine system and impairs the oxidant-antioxidant balance.
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Key Findings & Data:BPA (50 mg/kg) was orally administered to the BPA groups.
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Conclusion & Impact:Considering the widespread environmental exposure to BPA, PxG may represent a promising therapeutic agent for preventing BPA- induced hepatic and renal injury.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Bisphenol A · Panax ginseng · Liver

Abstract

Objective : Bisphenol A (BPA) is an industrial chemical that disrupts the endocrine system and impairs the oxidant-antioxidant balance. This study investigates the effects of Panax ginseng (PxG) on liver and kidney damage induced by BPA. Materials and Methods : Rats were divided into the control, control+PxG, BPA, and BPA+PxG groups. BPA (50 mg/kg) was orally administered to the BPA groups. PxG-treated groups were orally administered 100 mg/kg PxG five times per week for six weeks. At the end of the six weeks, liver and kidney tissue samples were taken for oxidative stress determination. Results: BPA administration significantly increased oxidative stress. PxG administration decreased BPA-induced oxidative stress, as evidenced by a reduction in lipid peroxidation and restoration of antioxidant enzyme activity in liver and kidney tissues. Conclusion: PxG exhibits hepatoprotective and nephroprotective effects. Considering the widespread environmental exposure to BPA, PxG may represent a promising therapeutic agent for preventing BPA- induced hepatic and renal injury.

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Cite This Article

Fazalyar, N., Yılmaz, S. K., Tufan, E., Muhan, A., Ak, E., Şener, G., Tunalı-Akbay, T. (2026). Panax ginseng Ameliorates Bisphenol A-Induced Liver and Kidney Damage in Rats. European Journal of Biology, Volume: 85 Issue: 2. https://doi.org/10.26650/EurJBiol.2026.1839519

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