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Journals / Ortadoğu Tıp Dergisi / 2026 / Cilt: 11 Sayı: 2

Giant Cell Carcinoma of the Lung: Management of Surgical Treatment

Funda İncekara(Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Thoracic Surgery, Ankara, Turkey)0000-0002-5872-3653
Ebru Sayılır Güven(Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Thoracic Surgery, Ankara, Turkey)0000-0002-6745-554X
Şevki Mustafa Demiröz(Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Thoracic Surgery, Ankara, Turkey)0000-0003-2471-6970
Merve Şengül İnan(Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Thoracic Surgery, Ankara, Turkey)0000-0001-5520-7314
Koray Aydoğdu(Health Sciences University, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Thoracic Surgery, Ankara, Turkey)0000-0003-1379-2855
Funda Demirağ(Health Sciences University, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Pathology, Ankara, Turkey)0000-0003-4790-8369
Selim Şakir Erkmen Gülhan(Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Thoracic Surgery, Ankara, Turkey)0000-0002-1143-9655
Sadi Kaya(Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Thoracic Surgery, Ankara, Turkey)0000-0002-9230-9720
Göktürk Fındık(Health Sciences University, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Thoracic Surgery, Ankara, Turkey)0000-0002-8861-7608
Pages
125–130
Publication Date
2019-06-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Complete surgical resection was found to be usefull as a treatment of choice of PGCC in the early stage and contributed to survival.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Pulmonary giant cell carcinoma (PGCC) is a histological type of nonsmall cell lung cancer and classified as one of the five subtypes of sarcomatoid carcinoma of the lung.
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Key Findings & Data:Material and Method: We represent our experience in the management of 7 patients (6 males and 1 female, with a range of 44-63 yr) with PGCC.
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Conclusion & Impact:Complete surgical resection was found to be usefull as a treatment of choice of PGCC in the early stage and contributed to survival.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Kemoterapi · dev hücreli karsinom · radyoterapi

Abstract

Objectives: Pulmonary giant cell carcinoma (PGCC) is a histological type of nonsmall cell lung cancer and classified as one of the five subtypes of sarcomatoid carcinoma of the lung. Pure PGCC is very rare. Material and Method: We represent our experience in the management of 7 patients (6 males and 1 female, with a range of 44-63 yr) with PGCC. The most representing symptoms were cough and hemoptysis. Upper lobectomy (n=7) and additionally mediastinal lymphadenectomy were performed in all patients. Results: Definitive histological examination confirmed the diagnosis of PGCC in all cases. Even though there was no perioperative mortality, postoperative complications developed in a case were hemorrhage in the early perioperative period and bronchus fistula after two months from the operation. The mean survival of the patients was estimated as 28.8 months (38 days - 116 months). Conclusion: The main treatment for PGCC is the complete surgical resection. Complete surgical resection was found to be usefull as a treatment of choice of PGCC in the early stage and contributed to survival.

Özet

Amaç: Pulmoner dev hücreli karsinom (PDHK) küçük hücreli dışı akciğer kanserinin bir histolojik tipidir ve akciğer sarkomatoid karsinomunun beş subtipinden biri olarak sınıflandırılır. Pür PDHK çok nadirdir. Gereç ve Yöntem: Kliniğimizde PDHK nedeni ile tedavi gören 7 hastayla ilgili tecrübelerimizi sunduk (6 erkek ve 1 kadın, yaş aralığı 46-63 yıl). En sık görülen semptomlar öksürük ve hemoptizi idi. Üst lobektomi (n=7) ve ek olarak mediastinal lenfadenektomi bütün hastalara uygulandı. Bulgular: Kesin histolojik inceleme ile tüm hastalarda PDHK tanısı doğrulandı. Herhangi bir perioperatif mortalite görülmemesine rağmen bir olguda ameliyat sonrası komplikasyon gelişti; erken perioperatif dönemde hemoraji ve operasyondan iki ay sonra bronşiyal fistül gelişti. Hastaların ortalama sağkalımı 28,8 ay (38 gün-116 ay) olarak bulundu. Sonuç: PDHK için asıl tedavi komplet cerrahi rezeksiyondur. Komplet cerrahi rezeksiyonun erken evre PDHK için yararlı bir tedavi tercihi olduğu ve sağkalıma katkı sağladığı bulunmuştur.

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Cite This Article

İncekara, F., Demiröz, Ş. M., Aydoğdu, K., Kaya, S. (2019). Giant Cell Carcinoma of the Lung: Management of Surgical Treatment. Ortadoğu Tıp Dergisi, Cilt: 11 Sayı: 2, 125–130. https://doi.org/10.21601/ortadogutipdergisi.440816

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