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Journals / Journal of Cellular Neuroscience and Oxidative Stress / 2025 / Volume: 17 Issue: 2

Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats with Scopolamine-Induced Dementia

Suleiman A. Muhammad
Asma'u D. Aliyu
Abdulsamad O. Abolaji
Amina Jiyah
Ibrahim Bulama
Abdulwasiu Ibrahim
Abdullahi Abbas
Mustapha U. Imam
Lawal Bilbis
Pages
1252–1260
Publication Date
2025-10-07
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, the results suggest that both vitamins exhibited neuroprotective properties by ameliorating oxidative stress and improving cognitive outcomes in dementia rats.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Alzheimer's disease (AD) is a neurodegenerative disorder that causes cognitive, behavioural, and personality declines.
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Key Findings & Data:After seven days of treatment with vitamins C and E, AD was induced in the rats on day eight by the injection of 4 mg/kg body weight of scopolamine.
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Conclusion & Impact:In conclusion, the results suggest that both vitamins exhibited neuroprotective properties by ameliorating oxidative stress and improving cognitive outcomes in dementia rats.
🔬Design:Text.Serial.Journal
📍Scope:Comprehensive Sample
⚙️Variables:Alzheimer · cognitive function · dementia

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that causes cognitive, behavioural, and personality declines. In the etiology of AD, oxidative stress has a main role. This study was carried out to investigate the neuroprotective effects of vitamins C and E on cognitive function and oxidative stress in rats with scopolamine-induced AD. After seven days of treatment with vitamins C and E, AD was induced in the rats on day eight by the injection of 4 mg/kg body weight of scopolamine. Behavioural outcomes such as anxiety, learning and memory were carried out using an elevated plus-maze, and novel object recognition tasks. Malondialdehyde (MDA), antioxidant enzymes, and vitamins were assessed in the brain tissue. Vitamins C and E treatment enhanced memory and behavioural functions in dementia rats when compared with the control group. The results also showed that the vitamin C and vitamin E treated groups had higher brain levels of vitamin C and vitamin E compared to the control group. Furthermore, both treatments reduced the MDA levels compared to the control group. The group that received either of the vitamins indicated higher superoxide dismutase and catalase activities compared to the control group. In conclusion, the results suggest that both vitamins exhibited neuroprotective properties by ameliorating oxidative stress and improving cognitive outcomes in dementia rats.

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Cite This Article

Muhammad, S. A., Aliyu, A. D., Abolaji, A. O., Jiyah, A., Bulama, I., Ibrahim, A., Abbas, A., Imam, M. U., Bilbis, L. (2025). Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats with Scopolamine-Induced Dementia. Journal of Cellular Neuroscience and Oxidative Stress, Volume: 17 Issue: 2, 1252–1260. https://doi.org/10.37212/jcnos.1741523

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