However, there is need to be done other genotoxicity tests for this active ingredient to support these results.
📌 3 Key Takeaways
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Objective & Hypothesis:Indapamide is an active ingredient of orally administered diuretic antihypertensive drug.
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Key Findings & Data:For this purpose, peripheral blood obtained from two healthy young donors, a man and a woman, was treated with four different concentrations (18,75; 37,50; 75,00 and 100,00 µg/ml) of indapamide in culture conditions for 24 and 48 h.
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Conclusion & Impact:However, there is need to be done other genotoxicity tests for this active ingredient to support these results.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:ASSESSMENT OF ANTIHYPERTENSIVE DRUG INDAPAMIDE GENOTOXICITY IN HUMAN PERIPHERAL LYMPHOCYTES USING CHROMOSOMAL ABERRATION TEST
Abstract
Indapamide is an active ingredient of orally administered diuretic antihypertensive drug. Genotoxicity data of indapamide are very limited and not detailed (in terms of doses, treatment period etc.). The purpose of this study was to evaluate the potential genotoxic effect of indapamide by using in vitro chromosomal aberration test. For this purpose, peripheral blood obtained from two healthy young donors, a man and a woman, was treated with four different concentrations (18,75; 37,50; 75,00 and 100,00 µg/ml) of indapamide in culture conditions for 24 and 48 h. A negative, a solvent (%75 methanol) and a positive control (mitomycin-C) were also applied for each treatment. According to these results, indapamide did not affect the frequency of chromosomal aberrations in all the concentrations and treatment periods. However, there is need to be done other genotoxicity tests for this active ingredient to support these results.
YILMAZ, E. A., YÜZBAŞIOĞLU, D., ÜNAL, F. (2017). ASSESSMENT OF ANTIHYPERTENSIVE DRUG INDAPAMIDE GENOTOXICITY IN HUMAN PERIPHERAL LYMPHOCYTES USING CHROMOSOMAL ABERRATION TEST. The Turkish Journal Of Occupational / Environmental Medicine and Safety, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 182–182. https://ajindex.com/articles/1008774
Ece Avuloğlu YILMAZ, Deniz YÜZBAŞIOĞLU1, Fatma ÜNAL Gazi University, Faculty of Science, Department of Biology, Genetic Toxicology Laboratory, Ankara-Turkey