Journals / Meandros Medical And Dental Journal / 2007 / Cilt: 8 Sayı: 1

General Features of Four CasesWith Oncocytic Change in Thyroid Tumors

TİROİDİN ONKOSİTİK DEĞİŞİKLİK GÖSTEREN TÜMÖRLERİNE DÖRT OLGU EŞLİĞİNDE GENEL BAKIŞ

Pages
35–37
Publication Date
2007-04-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We report 4 cases with oncocytic thyroid neoplasms that might have different biological and prognostic features.

📌 3 Key Takeaways

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Objective & Hypothesis:Oncocytic change in thyroid follicular cells can take place in a range of pathological conditions with Hashimoto's thyroiditis on the benign and Hurthle cell carcinoma or medullary carcinoma on the malignant ends of the spectrum.We evaluated four cases of thyroid tumors composed of oncocytic cells.
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Key Findings & Data:The tumors measured between 1 to 6 cm.
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Conclusion & Impact:We report 4 cases with oncocytic thyroid neoplasms that might have different biological and prognostic features.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hurthle hücresi · papiller karsinom · adenom

Abstract

Oncocytic change in thyroid follicular cells can take place in a range of pathological conditions with Hashimoto's thyroiditis on the benign and Hurthle cell carcinoma or medullary carcinoma on the malignant ends of the spectrum.We evaluated four cases of thyroid tumors composed of oncocytic cells. Three patients were women and one was a man. The tumors measured between 1 to 6 cm. Histologically all tumors showed oncocytic change in thyroid follicular cells.Two cases showed papillary features, and in the others the follicular growth pattern was predominant. In one case, the classical optically clear nuclei of papillary carcinoma were present. The rest had vesicular nuclei and prominent nucleoli. In two cases the peritumoral area showed the features of Hashimoto's thyroiditis. We report 4 cases with oncocytic thyroid neoplasms that might have different biological and prognostic features.

Özet

Tiroid follikül epitel hücrelerindeki onkositik değişiklikler benign uçta Hashimoto tiroiditi, malign uçta Hurthle hücreli karsinom yada medüller karsinom gibi geniş bir spektrumda izlenebilirler. Biz onkositik değişiklik gösteren dört tiroid tümörünü histopatolojik özellikleriyle tartıştık. Olguların üçü kadın biri erkektir. Tümörlerin boyutları 1-6 cm arasındadır. Histolojik olarak tüm tümörlerde follikül epitel hücrelerinde onkositik değişiklikler izlenmiştir. İki olguda papiller yapılanma izlenirken diğer ikisinde folliküler büyüme paterni izlenmiştir. Bir olguda tiroid papiller karsinomda tipik olarak izlenen nükleuslarda saydamlaşma dikkati çekmiştir. Diğer vakalarda nükleuslar vesiküle olup belirgin nükleol içermektedir.İki olguda tümör çevresindeki tiroid dokusunda Hashimoto tiroiditi bulguları izlenmiştir. Histopatolojik olarak birbirine benzeyen ve zaman zaman tanı zorluğu yaratan biyolojik davranış ve prognoz farklılığı göst mörü sunulmuştur.

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Cite This Article

TATAROĞLU, C., KESEN, Z. (2007). General Features of Four CasesWith Oncocytic Change in Thyroid Tumors. Meandros Medical And Dental Journal, Cilt: 8 Sayı: 1, 35–37. https://ajindex.com/articles/1002841

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References (10)

  1. DeLellis RA, Williams ED. Thyroid and parathyroid tumours. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C editors.World Health Organization Classification of Tumours. Pathology and genetic of tumours of endocrine organs. IARC Pres, Lyon, 2004;49-135
  2. Mai KT, Elmontaser G, Perkins G, Thomas J, Stinsson WA. Benign hurthle cell adenoma with papillary architecture: a benign lesion mimicking oncocytic papillary carcinoma. Int J Surg Pathol 2005;13(1):37- 41
  3. Berho M, Suster S. The oncocytic variant of papillary carcinoma of the thyroid: a clinicopathologic study of 15 cases. Hum Pathol 1997;28:47-53
  4. Baloch ZW, Livolsi VA. Pathology of thyroid and parathyroid disease. In: Mills SE, Carter D, Reuter VE, Greenson JK, Stoler MH, Oberman HA, editors. Sternberg's Diagnostic Surgical Pathology.4th ed. Lippincott Williams and Wilkins Publ, Philadelphia, 2004;557-661
  5. Gököz A. Tiroid bezi patolojisi. Kuzey GM, Özdamar ŞO, Zengeroğlu S, editörler. Temel patoloji. Güneş kitabevi,Ankara, 2007;757-767
  6. Beckner M, Heffess CS, Oertel JE. Oxyphilic papillary thyroid carcinomas. Am J Clin Pathol 1995;103:280- 287
  7. Herrera MF, Hay ID, Wu PS, Goellner JR, Ryan JJ, Ebersold JR, Bergstralh EJ, Grant CS. Hurthle cell (oxyphilic) papillary carcinoma of the thyroid: A variant with more aggresive biologic behavior. World J Surg 1992;16:669-675
  8. Bhattacharyya N. Survival and prognosis in hurthle cell carcinoma of the thyroid gland. Arch Otol Head Neck Surg 2003;129:207-210
  9. Goldstein NS, Czako P, Neill JS. Metastatic minimally invasive follicular and hurthle cell thyroid carcinoma: a study of 34 patients. Mod Pathol 2000;13(2):123-130
  10. Erickson LA, Jin L, Goellner JR, Lohse C, Pankratz VS, Zukerberg LR, Thompson GB, Heerden JA, Grant CS, Lloyd RV. Pathologic features, proliferative activity, and cyclin D1 expression in Hurthle cell neoplasms of the thyroid. Mod Pathol 2000;13:186-192.