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Journals / Journal of Clinical and Experimental Investigations / 2016 / Cilt: 7 Sayı: 3

The Relationship of Vitamin B12 Deficiency and Red Cell Distribution Width-Platelet Ratio

Nigar YILMAZ
Mustafa YILMAZ
Pages
211–213
Publication Date
2016-09-01
DOI
—
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J Clin Exp Invest 2016; 7 (3): 211-215

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We aimed to investigate the relationship between vitamin B12 deficiency and red cell distribution widthplatelet ratio (RPR), and the variations in the parameters on vitamin B12 treatment.
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Key Findings & Data:Methods: One hundred fifty-four patients with untreated vitamin B12 deficiency (56% men, mean age: 50 ± 12.7 years) (untreated group), 86 patients with vitamin B12 deficiency (62% men, mean age: 42 ± 20.7 years) on vitamin B12 treatment (treated group), and 92 age- and sex-matched control group (54% men, mean age: 45 ± 15.1 years) were included in the study.
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Conclusion & Impact:J Clin Exp Invest 2016; 7 (3): 211-215
🔬Design:Research Article
📍Scope:2016 Verileri
⚙️Variables:Vitamin B12 deficiency · red cell distribution width-platelet ratio · vitamin B12 treatment

Abstract

Objective: We aimed to investigate the relationship between vitamin B12 deficiency and red cell distribution widthplatelet ratio (RPR), and the variations in the parameters on vitamin B12 treatment. Methods: One hundred fifty-four patients with untreated vitamin B12 deficiency (56% men, mean age: 50 ± 12.7 years) (untreated group), 86 patients with vitamin B12 deficiency (62% men, mean age: 42 ± 20.7 years) on vitamin B12 treatment (treated group), and 92 age- and sex-matched control group (54% men, mean age: 45 ± 15.1 years) were included in the study. Hematological parameters were evaluated by the method of laser-based flow cytometric impedance, using an automated blood cell counter (ABX Pentra 120 Hematology Blood Analyzer). Results: RPR was significantly reduced in treated group compared with untreated group (4.88 ± 1.06; 6.13 ± 1.27; p<0.001, respectively). RPR, red cell distribution width (RDW) and mean platelet volume (MPV) were significantly different in untreated group compared to controls (p<0.05). There were no differences in platelet count in the three groups (p>0.05). Conclusion: We proposed that vitamin B12 deficiency has effects on RPR and supplementation with vitamin B12 corrects the RPR levels. J Clin Exp Invest 2016; 7 (3): 211-215

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Cite This Article

YILMAZ, N., YILMAZ, M. (2016). The Relationship of Vitamin B12 Deficiency and Red Cell Distribution Width-Platelet Ratio. Journal of Clinical and Experimental Investigations, Cilt: 7 Sayı: 3, 211–213. https://ajindex.com/articles/1001178

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