The Combined Use of SCD Probiotics and Tauroursodeoksikolik Asit (TUDCA) is More Effective in Controlling Anxiety-Like Behavior in Aged Rats

Abstract

In this study, the effects of TUDCA administration with a SCD probiotics for one week on locomotors activity and anxious behavior were investigated. Male Saprague-Dawley rats aged 24 months were used as the model organism. At the end of the application, open-field and elevated plus maze behavioral tests were performed on the rats. Although SCD probiotics were more effective on anxious behavior, the group in which they were administered together had a significantly greater effect on locomotor activity and anxious behavior. This study provides important evidence that combining SCD probiotics and TUDCA administration may be more beneficial to behavior.