Relationship Between The 18F-FDG Uptake with Ki-67 and P53 Expression in Patients with Lung Cancer: A Clino-Pathologic Study

Özet

Background: There have been some relationship between Ki-67 and P53 expression and the standardized uptake value (SUVmax) of the primary lesion duringpositron emission tomography-computed tomography (PET-CT) in lung cancers.Methods: The staining density of Ki-67 and p53 expression in 31 cases were diagnosed with non-small cell carcinoma (NSLCL) and 13 cases were diagnosed withsmall cell carcinoma (SCLC) have been investigated..Results: Ki-67 % was significantly correlated with SUVmax values in patients with lung cancer in all subtypes (adenocarcinoma, squamous and small celllung cancer) but the regression analysis was more prominent in adenocarcinoma and squamous cell carcinoma. Squamous cell carcinoma grouphad significantly correlated Ki 67 levels with overall survival (OS), and p53 levels had significantly correlated with progression free survival (PFS) andOS. Adenocarcinoma and small cell lung carcinoma patients did not have any significant correlation between the Ki 67, p53 and OS as well as PFS.Conclusions: There is a strong correlation between the SUVmax and pathologic staining of Ki 67 and p53. Squamous cell lung carcinoma subtype is highly expressedp53 and Ki 67 with might predicted by SUVmax and these findings are significantly correlated with oncologic outcomes. .Keywords: Ki 67, p53, SUV max, Lung cancer