SYNTHESES OF NEW POLYSUBSTITUED DIHYDROFURANS MEDIATED BY MANGANESE III ACETATE

Abstract

Efficient syntheses of new 4- hydroxymethyl -5,5-dimethyl-2- thiophen2-yl -4,5-dihydrofuran-3-carbonitrile 3a and 4- hydroxymethyl -5,5-dimethyl-2- phenyl-4,5-dihydrofuran-3-carbonitrile 3b were achieved via oxidative addition and cyclization reaction of 3-oxo-3- thiophen-2-yl propanenitrile 1a and 3-oxo-3- phenylpropanenitrile 1b with 3-methylbut-2-en-1-ol 2a in the presence of manganese III acetate. The structures of the compounds 3a and 3b were determined on the basis of spectral data IR, NMR and MS . All spectral data are in good agreement with the proposed structures of compounds.