Role of Protein Oxidation, Lipid Peroxidation and Antioxidant Defense Systems on Diabetes Mellitus

Abstract

Abstract: Diabetes; is a chronic disease whose prevalence has been increasing day by day in the world. Severalmechanisms have been causing the formation of diabetes. One of these mechanisms is the oxidative stress thatoccurs in cells and tissues. Oxidative damage which is caused by reactive oxygen species; has an important rolein the formation of complications due to diabetes. Hyperglycemia caused by diabetes increases free radicalformation. The antioxidant defense system tries to balance the toxic effects of reactive oxygen species. A, C, Evitamins and glutathione is Non-enzymatic antioxidants, and superoxide dismutase, catalase, glutathione peroxidaseand glutathione reductase is enzymatic antioxidants against reactive oxygen species. In this study; the balancebetween antioxidants and free radicals, the role of oxidative stress in diabetes and possible therapeutic effectswill be examined.