Schiff base derivatives with morpholine and antioxidant activity

Abstract

New Schiff base derivatives with morpholines, 4-bromo-2-(((4-morpholinophenyl)imino)methyl)phenol (I) and 4-bromo-2-(((2-morpholinoethyl) imino) methyl)phenol (II) were synthezised. The compounds I- II were characterized by spectral methods IR, and NMR spectroscopic techniques. Antioxidant activities of compounds I and II were determined by the ferric reducing ability of plasma (FRAP) assay method which is based on the reduction of Fe3+ -TPTZ complex to the Fe2+ -TPTZ complex in the presence of antioxidants. Compound I has relatively high ferric reducing power ability (i.e., antioxidant activity) than compound II. The ability of compound I and II to reduce iron (III) to iron (II) ions were calculated as 929 and 11 µM FeSO4.7H2O equivalent/g sample, respectively.To summarize, the above-mentioned results indicate that compound II has inefficient antioxidant activity and Compound I has effective antioxidant activity.