Relationship Between BCL-2 and Ki-67 in Chronic Sialadenitis

Abstract

Objective: Apoptosis or programmed cell death can be triggered by a variety of physiological and pathological signals. B-cell lymphoma-2 (Bcl-2) is an important anti-apoptotic protein of apoptosis pathways, mainly localized in intracellular membranes in mitochondrial outer membrane nuclear membrane and endoplasmic reticulum. BCL-2 family molecules can be stocked by upstream with irreversible cellular damage sites and have an important role in apoptosis studies. The best known antibody for identifying proliferating cells is Ki-67. There is a clear correlation between Ki-67 and the number of mitoses. Ki-67 is a nuclear protein that is believed to play a role in the early stages of rRNA synthesis ex- pressed in the G1, S, G2 and M phases except for the G0 phase of the cell cycle. In this study, we evaluated the expression of BCL-2 and Ki-67 in the pathogenesis of chronic sialadenitis.Methods: This study was included 18 cases of chronic sialadenitis. The immunohistochemistry BCL-2 and Ki-67 antibodies was performed in cases.Results: Statistically, there were significant correlation between BCL-2 and Ki-67 expression in acinar cells (p= 0.016). There was significant correlation between BCL-2 and Ki-67 expression in ductus and epimyoepithelial islands (p= 0.017). There was significant correlation between ductal and acinar cells on account of Ki-67 expression (p= 0.010). Conclusion: In this study, it was seen that decrease of BCL-2 and Ki-67 expression in acinar cells was higher than ductal epithelial cells.