Serum galectin-3 levels and vitamin D relationship in heart failure

Mustafa ÖZCAN, Murat AKARSU, Şengül AYDIN YOLDEMİR, Özgür ALTUN, Orkide KUTLU, Semih KALYON, Gülden YÜRÜYEN, Perihan ÖZKAN GÜMÜŞKAYA, Neslihan ÖZSOY, Hasan ERUZUN, Yücel ARMAN, Tufan TÜKEK

Abstract

Background/Aim: Heart failure is an important health problem with an increasing incidence in the world and poor prognosis. Galectin-3 is associated with progressive fibrosis, an underlying pathology of heart failure, just as vitamin D deficiency. We examined the relationship between the stage of heart failure and galectin-3 and 25-OH vitamin D levels. Methods: Sixty patients with heart failure and 30 healthy volunteers were included in this prospective case-control study. Demographic data, comorbid diseases and laboratory data were examined, and 25-OH vitamin D and galectin-3 levels were compared between the patients with CHF and the control group. Results: Galectin-3 levels were high in patients with heart failure (P