Evaluation of the relationship between disease activity and serum bilirubin, albumin, and uric acid levels in Crohn's disease

Abstract

Objective: Oxidative stress and antioxidant deficiency play key roles in the pathogenesis of gastrointestinal damage associated with Crohn's disease (CD). Serum bilirubin, uric acid (UA) and albumin are non-enzymatic antioxidants that play a role in oxidative stress control. In this study, it was aimed to evaluate the change in serum bilirubin, UA and albumin levels due to disease activity. Material and Method: This study was designed as a single-center, cross-sectional and retrospective. The clinical and demographic data of the patients, disease activity, as well as serum albumin, UA, and bilirubin values were recorded from the hospital database. Study variables were statistically analyzed between patient and control groups based on disease activity. Results: A total of 234 people, 114 with CD and 120 with controls, were included in the study. Total bilirubin, direct bilirubin and albumin levels were found to be significantly lower in the CD than in the health control (p=0.045, p