The role of inflammatory markers derived from complete blood count results in the diagnosis of intrahepatic cholestasis of pregnancy

Abstract

Objective: This study aimed to investigate complete blood count (CBC) markers, particularly those indicating systemic inflammation, in healthy subjects and those with mild and severe intrahepatic cholestasis of pregnancy (ICP). Material and Method: Seventy-nine subjects with ICP and 100 healthy age-matched women who were matched based on their scheduled singleton deliveries (on the same day) were included. ICP was defined as the increase in serum bile acid levels ≥10 μmol/L coupled with pruritus which could not be explained by other conditions. Patients with ICP were further categorized to mild and severe ICP according to bile acid levels, as follows: Mild ICP (