Dergiler / Eurasian Research in Sport Science / 2019 / Cilt: 4 - Sayı: 1
Profesyonel Voleybolcularda Katekol-O-Metiltransferaz (COMT) rs4680 Polimorfizminin Belirlenmesi
- Sayfa
- 1–6
- DOI
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Özet
Katekol-O-Metil Transferaz (COMT) katekolamin nörotransmitterlerin (dopamin, epinefrin,
Abstract
Catechol-O-Methyl Transferase (COMT) is involved in the inactivation of catecholamine neurotransmitters(dopamine, epinephrine, norepinephrine). The discovered functional polymorphisms in the COMTgene are known to cause changes in COMT enzyme activity. In our study, the Val (108/158) Met rs4680polymorphism of the COMT gene was examined in professional volleyball players and it was aimed todetermine the genotype and allele distributions of COMT rs4680 polymorphism in volleyball players.In this context, 21 professional volleyball athletes participated in our study. The genotyping study wascompleted with real-time polymerase chain reaction (RT-PCR) after swab DNA isolation. According tothe results of our study, AA, AG and GG genotype distributions in our athletes; In 6 of our athletes (29%),7 of our athletes (33%) had GA and 8 of our athletes (38%) had AA genotype. When we look at the allelnumbers of our volleyball players, G Allele was 19 (45%) and A Allele 23 (55%). AA genotype in ourcohort was higher than other genotypes, compared to A allele G allele. According to our findings, volleyballathletes’ low activity AA genotype has been proved to be a biomarker for predisposition to volleyball sport.Our study is the first research to examine the effect of COMT rs4680 polymorphism on volleyball players.