Dergiler / Turkish Journal of Medical Sciences / 2002 / Cilt: 32 - Sayı: 2
Antitumor Effects of TNF-b, 5-FU and Their Combinations on Cervical Carcinoma Cell Lines
- Sayfa
- 127–132
- DOI
- —
Özet
Cervical carcinoma is one type of cancer with a high mortality rate in females. In this study, we investigated the cytotoxic effects of TNF-b, 5-FU and their combinations on human cervical carcinoma cell lines, ME180 and HeLa. The highest degree of cytotoxic effect was obtained with 5-FU on both cell lines. While high concentrations of TNF-b showed cytotoxic effects on both cell lines, the lowest dose induced growth. Combination treatment of 5-FU and TNF-b gave a slightly higher cytotoxic and antiproliferative response compared to individual use of 5-FU and TNF-b on both cell lines.
Abstract
Cervical carcinoma is one type of cancer with a high mortality rate in females. In this study, we investigated the cytotoxic effects of TNF-b, 5-FU and their combinations on human cervical carcinoma cell lines, ME180 and HeLa. The highest degree of cytotoxic effect was obtained with 5-FU on both cell lines. While high concentrations of TNF-b showed cytotoxic effects on both cell lines, the lowest dose induced growth. Combination treatment of 5-FU and TNF-b gave a slightly higher cytotoxic and antiproliferative response compared to individual use of 5-FU and TNF-b on both cell lines.