Does Somatostatin Decrease Hemorrhage From Injured Liver in Rats?

Abstract

In portal hypertensive patients, somatostatin (SMT) and octreotide have been widely used to decrease variceal bleeding because of its splanchnic hypoperfusion effect. The aim of this study was to explore the effects of somatostatin treatment for decreasing blood loss of uncontrolled liver hemorrhage model in rats.Twenty-one male rats were divided into 3 groups including group 1; non-treatment, group 2; isotonic saline infusion and group 3; isotonic saline plus SMT infusion. Intra-abdominal bleeding was induced by transection of median lobe of liver. Mean arterial pressures (MAP), amount of intra-peritoneal blood collection and hematocrit (Hct) changes were evaluated for 60 minutes.There was no difference in the MAP changes between the groups until 25th minute. Thereafter, MAP remained similar in the group 1 while gradually increased (P