Kronik hepatit C virüs enfeksiyonlu Mısırlı bir hasta grubunda öksürük refleksi duyarlılığı çalışması

Study of cough reflex sensitivity in a group of Egyptian patients with chronic hepatitis C virus infection

Özet

Objective: The aim of this work was to study the effect of chronic hepatitis C viraemia on cough reflex sensitivity. Material and Method: Cough reflex sensitivity was tested by Capsaicin cough provocation in 57 patients (33.66±6.809 years old [M±SD]) with chronic HCV infection. Patients were divided into 3 subgroups: group I: 22 with normal Alanine aminotransferase (ALT) and no evidence of liver cirrhosis on ultrasound, group II: 19 with elevated ALT and active hepatitis but no cirrhosis on liver biopsy (8 on treatment) and group III: 16 with elevated ALT and positive cirrhosis on liver biopsy (6 on treatment). 23 normal age matched subjects were tested as controls. Results: log C5 was significantly lower in the three groups of patients than controls (p

Abstract

Amaç: The aim of this work was to study the effect of chronic hepatitis C viraemia on cough reflex sensitivity. Gereç ve Yöntem: Cough reflex sensitivity was tested by Capsaicin cough provocation in 57 patients (33.66±6.809 years old [M±SD]) with chronic HCV infection. Patients were divided into 3 subgroups: group I: 22 with normal Alanine aminotransferase (ALT) and no evidence of liver cirrhosis on ultrasound, group II: 19 with elevated ALT and active hepatitis but no cirrhosis on liver biopsy (8 on treatment) and group III: 16 with elevated ALT and positive cirrhosis on liver biopsy (6 on treatment). 23 normal age matched subjects were tested as controls. Bulgular: log C5 was significantly lower in the three groups of patients than controls (p