Çocuklarda brusellozis: 35 olgunun değerlendirilmesi

Özet

Brusellozisli 35 gocuk (3-14 yas) klinik, laboratuvar ve antibakteryel tedavi sonuglan dg-ismdan degerlendiril-di. Olgulann 22'si (%62.8) erkek, 13'u (%37.2) kizdi. Hastalann hepsinde enfeksiyon kaynagt gig silt veya gig siitten yaptlan urilnlerdi. Hayvancihkla ugrasan ailelerin gocuklanndafazlagorulmekteydi. Tani klinik semp-tom ve bulgularla birlikte yiiksek seviyede brusella agliitinasyon titresi He konuldu. Ates (%80) ve eklem agrtsi (%57.14) en sik karsilasilan semptomlardi. En sik bulunan bulgular splenomegali (%45.71) ve hepatomegaliy-di (%37-14). Anemi ve Ib'kopeni olgulann % 14.28'inde saptandi. ALTyuksekligi olgulann % 20'sinde saptan-di. Hastalara d&rt - alti hafta silreyle rifampisin + trimetoprim sulfometoksazol, tetrasiklin + streptomisin, gen-tamisin + trimetoprim sulfometoksazolgibi kombinasyonlar uygulandt. Ug gocukta (%8.57) relapsgoruldii. Re-laps gorulen olgular baslangigtaki kombinasyondan farkh antibakteryel ilagla basanyla tedavi edildi.

Abstract

Clinical and laboratory findings and antibacterial therapy results were evaluated in 35 children with brucel¬losis (3-14 years). Twenty two patients (62.8%) were male and 13 patients (37.2%) were female. Origins of the disease were uncooked milk or uncooked milk products in all patients. The disease was frequently seen in child¬ren of families who worked with animals. Jhe disease was diagnosed with symptoms, clinical findings and la¬boratory findings (eg. high brucella agglutination titration) of the disease. Fever (80%) and joint pain (57.14%) were the most frequent symptoms. Splenomegaly (45.71%) and hepatomegaly (37.14%) were the most frequent clinical findings. Anaemia and leukopenia was detected in 14.28 % of the cases. Elevated ALT was detected in 20 % of the cases. Rifampin + trimethoprim sulfamethoxazole or tetracyclin + streptomycin orgentamicin + tri-methoprim sulfamethoxazole combination was administered to patients for 4 or 6 weeks. Relapse occured in three children (8.57%). When relapse was occurred, the initial drug combination was changed and other drug combinations treated the patients successfully.