The role of protein oxidation in the development of diabetic microvascular complications

Yusuf Arslan, Cuma Mertoglu, Adalet Ozcicek, T. Abdulkadir Coban, Yucel Karakurt, Ozcan Erel, Gamze Gok, Gulsah Siranli, Alevtina Ersoy,

Abstract

OBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p