Effect of Statin Therapyin Tpe-Interval and Tpe/QTc Ratio in Patients with Familial Hypercholesterolemia

Abstract

Objective: Studies have shown that hypercholesterolemia can induce ventricular vulnerability to fibrillation, and statin therapy exerts antiarrhythmic effects.In the present study, we investigated the relationship between arrhythmogenic substrate and familial hypercholesterolemia(FH) with regard to statin therapy.Methods: We evaluated 46 statin-naive patients (41±12 years) with FH, and 46 healthy subjects (40±8 years) prospectively.Electrocardiography (ECG) of patients were compared before and after 6 months of intensive statin therapy and with controlgroups. The ECG parameters were calculated by two experienced cardiologists who blinded to each other’s findings.Results: There were no significant differences found between groups’ baseline characteristics. Total cholesterol (343±49 mg/dL vs. 161±12 mg/dL; p