Histopathological Effects of Boric Acid Solution on MiddleEar Mucosa in Guinea Pigs

Abstract

Objectives: In this study, we aimed to histopathologically reveal the effects of 4% boric acid solution used in diseasessuch as external otitis and otomycosis, in which the tympanum and tympanic membrane do not participate in theinfection process, on the healthy tympanic mucosa. Methods: A, B, C, D group guinea pigs were administered 4% boric acid solution for 7, 14, 21, 28 days respectively. Thetympanic bullae of group A, B, C, D guinea pigs were excised on the 8,15, 22,29 days respectively. Results: While 5 of the samples taken from the right tympanic bullae of group A were grade 2 and 1 was grade 3, allof the samples taken from the right tympanic bulla of the subjects in group B were grade 3, all samples taken from theright tympanic bullae of the subjects in group C were grade 4, and all of the right tympanic bullae of the subjects ingroup D were grade 4 regarding the histopathological changes. Conclusion: We determined that the use of 4% boric acid solution for more than 1 week in cases accompanied bytympanic membrane perforation such as chronic otitis media led to an increase in the inflammation score and histo pathological changes in the tympanic mucosa.