The Assessment of Resistant Hypertension-Related Cardiovascular Risk

Abstract

Objectives: The effect of resistant hypertension (RH) on cardiovascular risk has not been clarified. According to the ambulatory blood pressure monitoring (ABPM) results, cardiovascular disease outcomes are more common in patients withnon-dipping pattern. We aimed to show cardiac end-organ damages in RH and non-dipping patients within the RH.Methods: RH and regular hypertensive cases were included. Cardiovascular endpoints were determined as carotidintima-media thickness (CIMT), echocardiography parameters, and microalbuminuria. RH patients were divided intodipping and non-dipping groups according to the ABPM and the comparison of end-organ damage among themselveswas performed separately.Results: A total of 95 patients were enrolled, 61 in RH group. Significant differences were found between the RH andthe regular hypertensive group in terms of CIMT and microalbuminuria (p=0.020 for the right CIMT, p=0.016 for the leftCIMT, and p=0.003 for the microalbuminuria). There were no significant differences between the groups in resistant andregular hypertension (HTN) and also dipping and non-dipping groups in RH in terms of other parameters.Conclusion: Significant differences were detected between RH and regulated HTN patients in terms of CIMT and microalbuminuria, but there was no difference between the dipping and non-dipping groups in terms of atheroscleroticburden.