A study on effect of melatonin in dyslipidemia caused by experimentally diabetes

Abstract

In this study, it was aimed to determine the effects of melatonin application on lipid profile in streptozotocin-induced diabeticrats. Animals in control group were not any treatment. Melatonin group animals received 50 mg/kg melatonin intraperitoneallyin daily for eight weeks. Diabetes was induced by subcutaneous injections of streptozotocin at dose of 40 mg/kg for two days asa single dose per day in diabetes group animals. Animals in Diabetes+Melatonin group were made diabetic by streptozotocin inthe same way and then these animals received 50 mg/kg melatonin intraperitoneally in daily for eight weeks. In blood samplestaken from all animals, TNF-α, triglyceride, total cholesterol, LDL and HDL were determined. In diabetes group, TNF-α levelwere high (p