Effects of Melatonin on Some Antioxidant Enzymes in Streptozotocin-induced Diabetic Rats

Abstract

In this study, it was aimed to determine the effects of melatonin application in experimentally induced diabetes. For thispurpose, thirty two adult male Wistar Albino rats were used. Animals in control group were not any treatment. Melatoningroup animals received 50 mg/kg melatonin intraperitoneally in daily for eight weeks. Diabetes was induced by subcutaneousinjections of streptozotocin at dose of 40 mg/kg for two days as a single dose per day in diabetes group animals. Animals inDiabetes+Melatonin group were made diabetic by streptozotocin in the same way and then these animals received 50 mg/kgmelatonin intraperitoneally in daily for eight weeks. In blood samples taken from all animals, insulin, glucose, HbA1c, MDA,GSH, SOD were determined. The insulin level in diabetes group was lower than control group, while blood glucose level washigher (p