Effects of Curcumin on Hematological Parameters in Aflatoxin B1 Applied Rats

Abstract

In this study, it is aimed to determine the possible effects of curcumin on hematological parameters in aflatoxin appliedrats. Thirty eight healthy male Wistar Albino rats were used in the study. Group I animals was no applied. Animals in Group IIwere orally given 1 ml 10% DMSO daily for 60 days. Animals in Group III were orally given 300 mg/kg curcumin dissolved in10% DMSO daily for 60 days. Animals in Group IV were orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO daily for60 days. Animals in Group V was orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO and 300 mg/kg curcumindissolved in 10% DMSO daily for 60 days. At the end of the study, erythrocyte count, leukocyte count, platelet count,hemoglobin amount, hematocrit value, percentage ratios of leukocyte types, mean corpuscular volume (MCV), meancorpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) were determined in blood samplestaken from all animals. In the study, erythrocytes count, hemoglobin concentration, hematocrit value and MCHC level in theaflatoxin applied rats significantly decreased compared to the control group (p