Dergiler / Koşuyolu Heart Journal / 2010 / Cilt: 13 - Sayı: 2
Koroner Yavafl Akm Hastalarnda Apolipoprotein-B100 ve Apolipoprotein-A1 Arasndaki liflki
- Sayfa
- 11–15
- DOI
- —
Özet
Amaç: Koroner yavafl akm fenomenin (KYAF) altta yatan mekanizmas henüz tam olarak tanmlanmamfl olmas na ra¤men çeflitli hipotezler ileri sürülmüfltür. Bu çalflmamz da srasyla aterojenik ve anti-aterojenik etki gösteren plazma apolipoprotein-B100 (Apo-B) ve apolipoprotein-A1'in (Apo-A1) KYAF'deki rolünü arafltrdk. Yöntemler: Çalflmaya koroner anjiografik olarak KYAF'si olan 31 hasta (grup 1) ile normal kiflilerden oluflan 28 kontrol grubu (grup 2) ve koroner arter hastal¤ olan 30 hasta (grup 3) alnd. KYAF tans TIMI kare says yöntemiyle kondu. Gruplarn plazma Apo-B, Apo-A1, Apo-B/Apo-A1 oran ve demografik özellikleri karfllafltrld. Bulgular: Grup 1, 2 ve 3'deki ortalama Apo-B de¤erlerini srasyla 93±25 mg/dL, 90±26 mg/dL, 106±27 mg/dL olarak saptadk (grup 1 ile 3 arasndaki p=0.048, grup 2 ile 3 arasndaki p=0.041, grup 1 ile 2 arasndaki p= AD). Grup 1, 2 ve 3'deki ortalama Apo-A1 de¤erlerini srasyla 127±14 mg/dL, 125±21 mg/dL, 106±27 mg/dL olarak saptadk (grup 1 ile 3 arasndaki p=0.028, grup 2 ile 3 arasndaki p=0.021, grup 1 ile 2 arasndaki p= AD). Grup 1, 2 ve 3'deki Apo-B/Apo-A1 orann ise srasyla 0.73±0.18, 0.69±0.23 ve 0.98±0.20 olarak saptadk (grup1 ile 3 arasndaki p=0.017, grup 2 ile 3 arasndaki p=0.010, grup 1 ile 2 arasndaki p= AD). Sonuç: Koroner arter hastal¤ düflük plazma Apo-A1 düzeyi ile yüksek plazma Apo-B düzeyi ve Apo-B/Apo- A1 oran ile iliflkilendirilmifl olmasna ra¤men apolipoproteinler ile KYAF arasnda bu iliflki bulunmamfltr.
Abstract
Objective: Although several hypotheses have been suggested, the underlying mechanism of coronary slow flow phenomenon (CSFP) has not been well established yet. The aim of this study was to determine the roles of plasma apolipoprotein-B100 (Apo-B) and apolipoprotein-A1 (Apo-A1) in CSFP which have an atherogenic effect and anti-atherogenic effects respectively. Methods: The study consisted of 31 patients with CSFP (group 1), 28 normal subjects as control group (group 2) and 30 patients with coronary artery disease (CAD) (group 3) detected by coronary angiography. CSFP was diagnosed by the TIMI frame count method. Blood Apo-B, Apo-A1, Apo-B/Apo-A1 ratio, and demographic parameters were compared between the groups. Results: The Apo-B values were 93±25 mg/dL, 90±26 mg/dL, and 106±27 mg/dL in groups 1, 2 and 3, respectively (p=0.048 between group 1 and 3, p=0.041 between group 2 and 3, p= NS between group 1 and 2). The Apo-A1values were 127±14 mg/dL, 125±21 mg/dL and 106±27 mg/dL in groups 1, 2 and 3 respectively (p=0.028 between group 1 and 3, p=0.021 between group 2 and 3, p= NS between group 1 and 2). The apo- B/apo-A1 ratio were 0.73±0.18, 0.69±0.23 and 0.98±0.20 in groups 1, 2 and 3 respectively (p=0.017 between group 1 and 3, p=0.010 between group 2 and 3, p= NS between group 1 and 2). Conclusion: Although lower levels of plasma Apo-A1 and higher levels of Apo-B and the ratio of Apo-B to Apo-A1 are related with CAD, there is no relationship between these apolipoproteins and CSFP.