Dergiler / Koşuyolu Heart Journal / 2010 / Cilt: 13 - Sayı: 2
Koroner Yavafl Akm Fenomeniyle Dehidratasyon ve Hemokonsantrasyon Belirteçlerinin liflkisi
- Sayfa
- 6–10
- DOI
- —
Özet
Amaç: Patofizyolojik olarak az bilinen koroner yavafl akm fenomeni (KYAF) distal koroner arterin boyanma hznn azalmas ile karekterize anjiografik bir fenomendir. Çeflitli hipotezler ileri sürülmüfl olsada KYAF'nin mekanizmas tam olarak açklanmamfltr. Bu çalflmann amac dehitratasyon ve hemokonsantrasyon belirteçlerinin KYAF'de kan akm anomalisindeki rolünü belirlemektir. Yöntemler: Çalflmaya anjiografik olarak 33 KYAF'si olan hasta (grup 1) ile 31 normal olan kontrol grubu hasta alnmfltr. KYAF tans TIMI frame saym metodu ile konmufltur. Serum elektrolit, osmolarite, ve hematolojik parametreler ölçülmüfltür. Bulgular: KYAF hastalarnda kontrol grubuna göre hesaplanmfl osmolarite, tonisite, sodyum, glukoz, ve kan üre nitrojen düzeyi daha yüksek saptanmfltr. Ayrca total kolesterol, albumin hariç hematokrit, hemoglobin ve hesaplanm fl osmolarite de anlaml fark saptanmfltr. Sonuç: Bu çalflmamz KYAF ile hemokonsantrasyon ve dehitratasyon belirteçlerinin anlaml olarak iliflkili oldu¤unu göstermifltir. Bu belirteçler koroner kan akm anomalisinde önemli olabilir.
Abstract
Objectives: The coronary slow flow phenomenon (CSFP), characterized by decreased distal progression of dye to coronary arteries, is a distinct angiographic phenomenon and little is known about its pathophysiology. Although several hypotheses have been suggested, the underlying mechanism of CSFP has not been well established yet. The aim of this study was to determine the roles of indicators of dehydration and haemoconcentration in CSFP which have blood flow abnormality effects. Methods: The study consisted of 33 patients with CSFP (group 1), and 31 normal subjects as control group (group 2) detected by coronary angiography. CSFP was diagnosed by the TIMI frame count method. Serum electrolytes, osmolarity and haematological parameters were measured. Results: Compared with control subjects, patient with CSFP had increased levels of calculated osmolarity, tonicity, sodium, glucose and blood urea nitrogen (BUN). Significant differences were also observed in the haematocrit, haemoglobin concentration, and calculated osmolarity but not in total cholesterol and albumin. Conclusions: The results of the present study indicate that the markers of haemoconcentration and dehydration are significantly associated with CSFP. The markers may be important in the coronary blood flow anomaly.