Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland

Abstract

Water-clear cell adenoma of the parathyroid gland is a rare neoplasm that consists of cells with abundant clear-pink cytoplasm. There haveonly been 19 cases reported in the English literature. Here we report a case of water-clear cell adenoma of the mediastinal parathyroid gland.A 70-year-old male patient presented to the hospital with back pain and a mediastinal mass 6 cm in size was detected. After excision andmicroscopic evaluation, uniform, large clear cells with fine cytoplasmic vacuolization, without nuclear atypia, and arranged in solid and acinarpatterns were revealed. The cells formed nests that were separated by fine fibrovascular septae and stained positively with anti-parathyroidhormone. To the best of our knowledge, this has not been previously reported in this location. In the differential diagnosis of clear cell lesions ofthe mediastinum, water-clear cell parathyroid adenoma should be considered.