Uterine Leiomyoma with Massive Lymphoid Infiltrate in a Patient with History of Assisted In-Vitro Fertilization

Abstract

Uterine leiomyomas are the most common benign tumors of the gynecological tract. Massive lymphocytic infiltration has been reported rarely inuterine leiomyomas and it has been described as a pathogenetic correlation with gonadotropin-releasing hormone agonists. Uterine leiomyomaswith massive lymphoid infiltration have to be differentiated from non-Hodgkin lymphomas. We report a case of a woman without a historyof gonadotropin-releasing hormone agonist treatment, who presented with a uterine leiomyoma that increased in size after the procedure ofassisted in-vitro fertilization, and associated with massive nodular lymphoid infiltrate simulating, morphologically, a non-Hodgkin lymphoma.Uterine leiomyoma with massive lymphocytic infiltration is a very rare entity, probably of reactive significance, which has to be differentiatedfrom diseases that need a systemic therapeutic approach.