Effective Treatment of Undiferentiated Pleomorphic Sarcoma Using Gemcitabine: A Case Report

Abstract

Undifferentiated pleomorphic sarcoma (UPS) is most frequently observed in the extremities but rarelyin the retroperitoneum. The present treatment for patients with metastatic or unresectable UPS in thefirst-line setting includes doxorubicin administration with or without ifosfamide. We present a case ofa 68-year-old woman who presented with a retroperitoneal giant mass. The patient underwent surgery,the mass was removed, and the final diagnosis was UPS. The postoperative stage included soft tissuemetastases. After three cycles of gemcitabine chemotherapy, computed tomography findings revealed theabsence of soft tissue metastases. The patient has remained on regular follow-up over the past two yearssince chemotherapy with no symptoms of disease recurrence. The findings of this case demonstrate thatpatients with retroperitoneal UPS may benefit from single-agent gemcitabine chemotherapy.