An incidentally Diagnosed Hepatocellular Carcinoma That Exhibited Unusual Metastasis

Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It can be diagnosed at alate stage due to the lack of early symptom onset and its non-pathognomonic symptoms. Metastaticregions often include the lung, lymph nodes, bones, and adrenal glands. Soft tissue and central nervoussystem (CNS) metastases are extremely rare. The incidence of CNS metastasis ranges from 0.6% to1.7%. Curative treatment is liver transplantation or resection in early stages. In advanced stages, localtherapies include transarterial chemoembolization and radioembolization. Systemic treatments, such assorafenib, regorafenib, ramucirumab, and nivolumab, are applied in the metastatic stage. We aimed topresent with literature the case of HCC that was diagnosed incidentally and had rare metastasis of softtissue and CNS and long-term overall survival.