The Prognostic Effects of Temporal Muscle Thickness and Inflammatory-Nutritional Parameters on Survival in Lung Cancer Patients with Brain Metastasis

Abstract

OBJECTIVEBrain metastasis develops in one-third of the patients with adult cancer and it causes significant morbid-ity and mortality on the patients. In this study, we aimed to show the prognostic effects of temporal mus-cle thickness and inflammatory (neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic inflammation response index) and prognostic nutritional index on survival in lung cancer patients with brain metastasis.METHODSIn this study, a total of 94 cancer patients diagnosed with brain metastasis lung cancer were evaluated retrospectively. Routine blood sampling was tested within 10 days of brain MR imaging before the use of steroid therapy.RESULTSTemporal muscle thickness was significantly associated with overall survival, according to cut-off 4.32 (95% CI 0.66-0.99; p=0.040). The risk of death increased by 18.8%, with every millimeter reduction in tem-poral muscle thickness. Neutrophil-lymphocyte ratio, systemic inflammation response index and prog-nostic nutritional index were associated with overall survival (p=0.002, p=0.008, p=0.001, respectively).CONCLUSIONThe findings showed that the use of temporal muscle thickness and inflammatory-nutritional param-eters for the evaluation of sarcopenia were practical and rapid methods. In this group of patients with a short duration of survival, the prognosis of patients can be predicted, and their exposure to toxic treat-ment may be prevented by the evaluation of sarcopenia.