Kronik böbrek hastalarında ürik asit ve d vitamini düzeyleri arasındaki ilişki

The association between uric acid and vitamin D levels in patients with chronic kidney disease

Özet

AMAÇ: Hiperüriseminin D vitamini düzeyini düşürdüğü ileri sürülmektedir. Bu çalışmanın amacı, kronik böbrek hastalarında serum ürik asit düzeyi ile D vitamini düzeyleri arasında bir ilişkinin olup olmadığını incelemektir.GEREÇ ve YÖNTEMLER: Çalışma, evre 3-4 kronik böbrek hastalığı olan 35 hastada yapıldı. Hastaların biyokimyasal incelemeleri, D vitamini düzeyleri, 24 saatlik idrarda kreatinin klirensleri ve proteinüri incelemeleri değerlendirildi. Sistolik ve diyastolik kan basıncı ölçüldü. İstatistiksel analizler bilgisayarda SPSS 15.0 Windows versiyonu kullanılarak gerçekleştirildi. p

Abstract

OBJECTIVE: Hyperuricemia has been said to decrease vitamin D level. The purpose of this study is to examine whether there is an association between serum uric acid and vitamin D levels in patients with chronic kidney disease.MATERIAL and METHODS: This study was performed in 35 patients with stage 3-4 chronic kidney disease. Biochemical tests, vitamin D level, 24 hour urine creatinine clearance, and proteinuria were analysed. Systolic and diastolic blood pressure were measured. The statistical analysis was performed using SPSS version 15.0. A P value of less than 0.05 was considered statistically significant.RESULTS: Serum 1,25(OH)2D3 and 25(OH)D3 levels were low in 28 patients (80%) and in 24 patients (69%) respectively. Data analysis revealed statistically significant associations between serum uric acid and body mass index, 1,25(OH)2D3, creatinine, and phosphorus levels (P=0.04, P=0.03, P=0.01 and P=0.001, respectively).CONCLUSION: Our study demonstrates that there is a significant negative association between serum uric acid and 1,25(OH)2D3 levels. However, further studies are needed in a larger number of patients.