Marmara bölgesi kohortunda apolipoprotein C-III düzeyleri ve diğer risk faktörleri ile ilişkileri

Apolipoprotein C-III levels and interrelation with other risk factors in residents of the Marmara region

Altan ONAT, Ömer UYSAL, Gülay HERGENÇ, Vedat SANSOY, İbrahim KELEŞ, Ali ÇETİNKAYA, Köksal CEYHAN, Beytullah YILDIRIM

Özet

TEKHARF çalışmasının Marmara bölgesi örnekleminin bir rastgele bölümünde kesitsel yapılan bu araştırmada, 259 erkek ve kadında (ortalama yaş 50±12) trigliseridden zengin lipoprotein (TZL) metabolizmasını yakından etkileyen apolipoprotein C-III (apoCIII) düzeyleri incelendi. Total apoCIII ve HDL-apoCIII türbidimetrik kit ile otoanalizörde ölçüldü; HDLdışı-apoCIII hesaplandı. Diğer risk parametreleri ve koroner kalp hastalığı (KKH) tanısı, TEKHARF çalışmasının mutad yöntemleriyle belirlendi. Ortalama HDLdışı-apo CIII normolipidemik (trigliserid

Abstract

Aortic regurgitation (AR) severity is generally assessed by conventional echo-Doppler methods which are affected by both technical and hemodynamic variables. Vena contracta (VC) width has been previously shown to be less influenced by hemodynamic variables and correlate with angiographic grading of mitral regurgitation. However, clinical application of VC has been limited because of the difficulty in clear imaging the VC by transthoracic echocardiography (TTE) in patients with AR. To our knowledge, there is only one study which evaluates VC method in AR by transesophageal echocardiography (TEE) in the literature. This study was designed to compare aortic VC width by multiplane TEE with quantitative Doppler echocardiography and angiographic grading. The VC width was measured at the narrowest portion of the AR jet as it emerged through the coaptation of leaflets; it was clearly imaged in 48% of patients by TTE and 88% of patients by TEE. Transesophageal echocardiographic VC width correlated well with regurgitat ion volume (r=0.91, p