Batı bölgelerimiz erişkinlerinde kanda C-reaktif protein ile fibrinojen düzeyleri ve diğer risk faktörleriyle ilişkileri

Distribution of proinflammatory markers and their interrelation with other cardiovascular risk parameters among Turks

Altan ONAT, Ömer BAŞAR, Burak ERER, Gülay HERGENÇ, Vedat SANSOY, Ali ÇETİNKAYA, Köksal CEYHAN

Özet

TEKHARF kohortunun 10. yıl takibinde Türkiyenin üç Batı bölgesinde, 524'ü erkek, 522'si kadın olmak üzere, 1046 kişilik bir grubunda, kan basıncı, kan yağları, antropometrik özelliklerin yanısıra akut faz reaktanlarından C-reaktif protein (CRP) ile fibrinojen ölçüldü; fizik aktivite, sigara kullanımı, gelir düzeyi gibi yaşam tarzı ile ilgili bilgiler tespit edildi. Kardiyovasküler sistemin anamnez, fizik muayenesine ve istirahat EKG'ının Minnesota kodlamasına göre kesin veya şüpheli 96 koroner kalp hastası (KKH) belirlendi. Yaş ortalamaları (51±13) farketmeyen kadın ve erkeklerde kanda CRP geometrik ortalama (2.00 / 1.90 mg/L) ve fibrinojen ortalama değerleri (3.40±1.16 / 3.15±1.17 g/L) arasında anlamlı bir fark bulunmadı. CRP ve fibrinojen düzeyleri arasında ilişki anlamlıydı (p

Abstract

In a representative sample population of three Western regions of Turkey, comprising 1046 adults aged 30 or over, acute phase reactants blood fibrinogen and C-reactive protein (CRP) were measured as were blood pressure, anthropometric measures, plasma lipids and lipoproteins; in addition, smoking status and physical activity grade were assessed. Coronary heart disease was diagnosed based on clinical findings and on Minnesota coding of resting electrocardiograms. Mean age of men and women was similar: 50.8 ±12.6 and 51.2±13.1 years, respectively. No significant difference existed in the genders regarding the means of CRP (geometric, 1.9 and 2.0 mg/L) and of fibrinogen (3.15±1.17 and 3.40±1.16 g/L). The two inflammatory markers were significantly correlated (r = 0.26) with each other. CRP concentrations were correlated with the components of the metabolic syndrome X and with all the other measured risk parameters except for smoking status. In men, CRP was correlated in particular with measures of (central) obesity, apolipoprotein B, blood pressure and fibrinogen. As independent determinants emerged for CRP values, age, fibrinogen, waist circumference, total cholesterol, and (inversely) physical activity grade. Independent associations with fibrinogen levels were observed for age, waist-to-hip ratio, CRP quartiles, smoking status and (inversely) physical activity grade. When mean values in apparently healthy subjects for fibrinogen (3.4 g/L) and CRP (1.86 mg/L) were compared with those in patients with CHD (3.7 g/L and 3.97 mg/L, respectively), CRP (p