The relationship between epicardial adipose tissue and P wave and QT dispersions

Akif Serhat BALCIOĞLU, Turan ERDOĞAN, Ömer ŞATIROĞLU, Murtaza Emre DURAKOĞLUGİL, Hakan DUMAN, Yüksel ÇİÇEK, Zakir KARADAĞ, Sıtkı DOĞAN, Mehmet BOSTAN

Özet

Amaç: Epikardiyal adipoz doku (EAD) kalpte pek çok endok- rin ve parakrin etkiye sahip olan çeşitli enflamatuvar ve atero- jenik ajanları salgılar. Bu çalışmada, EADnin elektrokardiyo- gafinin (EKG) basit, non-invaziv aritmi belirteçleri olan QT veP dalga dispersiyonu (QTd, PDd) üzerine etkisini araştırmayıplanladık. Yöntemler: Kesitsel yapıda çalışmamıza koroner arterle- ri normal 70 hasta alındı. Bu hastalara 12 derivasyon EKG,ekokardiyografi, biyokimyasal çalışmalar yapılarak, QTd, PDdve EAD kalınlığı hesaplandı. Bulgular: Ortanca EAD 4.1 mm olarak bulundu. EAD yaş(r=0.412, p

Abstract

Objective: Epicardial adipose tissue (EAT) secretes various pro- inflammatory and atherogenic mediators that have several en- docrine and paracrine effects on heart. This study investigatedthe influence of EAT on QT and P wave dispersions (QTd, PWd),as simple, non-invasive tools of proarrhythmia on surface ECG. Methods: This was a cross-sectional study and included70 patients with normal coronary arteries who underwent12-derivation electrocardiography, echocardiography and bio- chemical examinations in order for QTd, PWd, and EAT thick- ness to be measured. Results: Median EAT thickness was 4.1 mm. Correlationanalyses revealed that EAT was significantly associated withage (r=0.412, p