Influences of cardiac resynchronization therapy on cardiac biomarkers in patients with chronic heart failure

Abstract

Cardiac resynchronization therapy (CRT) is an established therapy for patients with heart failure(HF) and reduced ejection fraction who have a significant left ventricular (LV) conduction delay, as it hasbeen proven to reduce morbidity and mortality. However, one-third of patients don’t respond favorably toCRT and therefore, the identification of patients whowould be most likely to benefit from CRT has a special importance. Left bundle branch block (LBBB)QRS morphology, QRS duration >150 milliseconds,non-ischemic etiology, and female gender are referredas strong predictors for better outcomes of CRT. Inaddition, it should be emphasized that recent HFguidelines do not recommend CRT in patients with aQRS duration