Hepatit B aşısına yanıtsızlıkta düşük düzey taşıyıcılık

Importance of low level carrier state in nonresponsiveness to hepatitis B vaccination

Özet

Bu cah§mada, risk grubunda oldugu gerekcesiyle uygulanan hepatit B asisina yanit venneyen bireylerde, dii-§iik diizey tasiyicihk durumu ve HBV-DNA varhgmm asi yanitsizhgmdaki rolii arastmlmi§, aynca yanitsiz bireylerin, asi yanitsizligma neden oldugu bilinen kimi faktorleryonilnden ozellikleri gozden gecirilmigtir. Asi uygulamasina yanit venneyen 41 bireyden gahsma grubu; asiya yanit vermis, cahgma grubu ile yas ve cinsi-yet ozellikleri bakimmdan e§le§tirilmi§ 36 bireyden ise kontrol grubu olusturulmustur. (Jah§manin bulgulart-na gore, cahsma grubundaki sigara igenler ile vilcut kitle indeksi 25'in iizerinde olanlann orani, kontrol gru-buna gore daha yuksektir ve istatistiksel olarak anlamhya oldukga yakm bir sonug vermektedir. Asiya yanitsiz bireylerin serumunda polimeraz zincir reaksiyonu ile HBV-DNA aranmi§ ve 41 birey iginde, turn HBVserolo-jik gostergeleri negatifolan bir bireyde HBV-DNA pozitifsaptanmistir. Bu bulgulardan yola gikarak hepatit B asisma yanitsizlarda, viicut agirhgi ve sigara igiminin asi yanitsizhgi ile ilgili faktorler oldugu; asi yanitsizh-gmda, dusuk diizey tasiyicihk durumu ve HBV-DNA varhginin onemli birfaktdr olarak yer almadigi soylene-bilir.

Abstract

In this study, we have investigated the role of low level carrier state and presence of HBV-DNA in a group of nonresponders to hepatitis B vaccination. Besides, nonresponder group has been compared with a control gro¬up that consisted ofresponders to HBV vaccination, about factors that are known to effect immunization such as cigarette smoking and obesity. Nonresponder group (n=41) was matched with the control group (n=3& by age and sex. According to our findings, the proportions of smokers and persons with body mass index higher than 25 in the nonresponder group were higher than the same proportions in the control group and statistical analysis gave tendency to significance. 41 persons in the nonresponder group were screened by polimerase chain reaction whether they were carriers of HBV-DNA or not and HBV-DNA was detected in a patient with no serologic markers of recent or past HBV infection,,'As a result, body weight and smoking were found to be asso¬ciated with nonresponsiveness to hepatitis B vaccination, low level carrier state and presence of HBV-DNA was not an important factor that contributes to nonresponsiveness.