Effects of heparin-bonded pump systems on haemostatic parameters and postoperative bleeding

Heparin kaplı pompa sistemlerinin hemostatik belirleyiciler ve postoperatif kanama miktari üzerine etkileri

Mustafa YILMAZ, İbrahim Celalettin HAZNEDAROĞLU, Rıza DOĞAN, İlhan PAŞAOĞLU, Erkmen BÖKE

Özet

Kardiyopulmoner bypass, kanin yabana yilzeylerle temasi sonucu hemostatik sistemlerde degisikliklere yol agar. Heparin kapli pompa sistemlerinin gelistirilmesi, pompa sistemlerinin tromboresiztansinin artmasina ve daha biyolojik pompa yuzeylerinin kulammina yol acmisttr. Heparin kaphpompa sistemlerinin etkinligi post¬operatif kanama miktari, hemoglobin, hematokrit, trombosit sayisi, protrombin zamani, aktive parsiyel trom-boplastin zamani, fibrinojen duzeyi, fibrin yikim urilnleri, INR ve D- dimer dilzeyleri saptanarak arastmlmisttr. Bu gahsma heparin kapli pompa sistemlerinin agik kalp cerrahisinde daha biyo uyumlu yiizeyler sundugunu gostermektedir.

Abstract

Cardiopulmonary bypass (CPB) causes changes in the haemostatic system partly by exposing blood to large foreign surfaces and materials in the extracorporeal circuits and partly due to the nonphysiological parame¬ters of the CPB. Development of heparin-coated CPB circuits is one of the improvements to create a biocompati-ble circuit surfaces and allowed to increase thromboresistance of the circuits. Efficiency of the heparin-coated surfaces was evaluated by comparing the post-operative bleeding, hemoglobin, hematocrit, platelet counts, pro-trombin time, activated partial thromboplastine time, fibrinogen level, fibrine degradation product, interna¬tional normalised ratio, D-dimer levels in this study and the results favoured the use of the heparin-coated sys¬tems