Erzincan’da Alerjik Astımlı Hastaların Ev Tozu Akar Alerjenlerine Karşı Duyarlılığı

Sensitivity to House Dust Mites Allergens in Patients with Allergic Asthma in Erzincan Province, Turkey

Özet

Amaç: Alerjik astımlı (AA) hastaların ev tozu akarlarına (ETA) karşı olan duyarlılığını deri testi ile değerlendirmek, hastaların Dermatophago- ides pteronyssinus ve Dermatophagoides farinae’ye karşı spesifik IgE ve total IgE antikorlarını ölçmek ve hasta evlerindeki toz akar faunası araştırmak amaçlandı. Yöntemler: Çalışmaya Der p ve Der f akar alerjenleri ile deri testi yapılan AA’lı 25 hasta ve 31 sağlıklı kontrol alındı ve kan serumunda alerjene özgü IgE ve total IgE seviyeleri ölçüldü. Tüm katılımcıların evlerinden toz örnekleri toplanarak gram tozdaki akar sayısı ve türleri bakımından incelendi. Bulgular: Deri testinde pozitif Der p reaksiyonu görülen hastaların %94,7’sinin evinde Dermatophagoides pteronyssinus (p

Abstract

Objective: To investigate the sensitivity of allergic asthma (AA) patients to house dust mites (HDM) by conducting skin tests, measuringtotal and specific IgE antibodies to Dermatophagoides pteronyssinus and D. farinae mites, and examining HDM fauna in patients’ homes.Methods: The study included 25 patients with AA and 31 healthy controls, who were challenged with Der p and Der f allergens; serum levelsof allergen-specific lgE and total IgE were measured. Dust samples were collected from the homes of all participants, and mite species andthe number of mites per gram of dust were investigated.Results: D. pteronyssinus was found in the homes of 94.7% patients with positive Der p reactions in the skin test (p0.05). D. pteronyssinus-specific IgE was detected in 75%patients in whose homes D. pteronyssinus was also found, while D. farinae-specific IgE was detected in 16.6% patients in whose homes D.farinae was also found.Conclusion: A part of AA patients residing in Erzincan are sensitive to HDM allergens, and high numbers of mites leading to allergic sensi-tization are found in their homes.