Gonartrozlu hastaların tedavisinde intraartiküler hyaluronik asit ve rofekoksib etkinliğinin karşılaştırılması

Comparison of efficacy of hyaluronic acid and rofecoxib in the treatment of patients with gonarthrosis

Özet

Çalışmamızdaki amaç, gonartrozlu hastalarda İntraartiküler hyalüronik asit (HA) ve rofekoksib etkinliğini karşılaştırmaktı. 39 gonartozlu hasta değerlendirildi (33 kadın, 6 erkek). Randomize olarak seçilen 21 hastaya 5 hafta süreyle haftada bir İntraartiküler HA 25 mg uygulandı ve 18 hastaya ise 5 hafta süreyle rofekoksib 25 mg tab 1x1 verildi. Ağrı süresi kaydedildi ve radyolojik sınıflandırma yapıldı. Tedavi başlangıcında, 3, 5 ve 8 hafta sonunda, VAS ile spontan ve aktivite sonundaki ağrı ölçüldü. Hastaların fonksiyonel kapasiteleri WOMAC testi kullanılarak değerlendirildi. Yaş, cinsiyet, ağrı süresi ve radyolojik değerlendirme açısından gruplar arasında fark yoktu (p>0,05). Varyans analizi ile dört ayrı zamanda yapılan değerlendirmede, her iki tedavi grubunda da VAS ve WOMAC skorlarında istatistiksel anlamlı düzelme saptandı (p0,05). Fonksiyonel düzeyin WOMAC ile değerlendirilmesi sonucunda, İntraartiküler HA uygulanan grupta, rofekoksib uygulanan gruba göre anlamlı düzelme görüldü (p

Abstract

The purpose of this study was to compare the efficiency of Intra articular hyaluronic acid and rofecoxib in patients with gonarth-rosis. 39 patients were enrolled in the study (33 women, 6 men), in randomly selected, 21 patients intraarticular hyaluronic acid was applied önce a week, 5 times and 18 patients were given rofecoxib 25 mg once a day for 5 weeks. Pain duration was recorded and radiological classification was made. At the beginning of the treatment and at the end of the 3 rd, 4th WOMAC was used to evaluate the functional capacity of the patients. There was no difference between the two groups according to age, sex, duration of pain and radiological classification (p>0.05). in both treatment groups statistically significant imp-rovement was determined in the VAS and WOMAC scores using variance analysis according to four evaluations made at four different times (p0.05). Statistically significant improvement was found in the intraarticular HA group compared to the rofeco-xib group by using WOMAC. Rofecoxib was more effective than HA in the 50 feet walking duration and stiffness according to WOMAC. As a result; both rofecoxib and intraarticular HA were effective in the treatment of pain in patients with gonarthrosis. Rofecoxib was more effective in 50 feet walking duration and stiffness, but intra articular HA injection was more effective in improvement of the daily living activities and functional capacity.