[Hesperidin ve öjenol, oksidatif stres, Bax/Bcl2 ve bölünmüş kaspaz 3 ekspresyonunun düzenlenmesi yoluyla kadmiyum kaynaklı nefrotoksisiteyi zayıflatır]

Abstract

Objectives: Cadmium (Cd) is a heavy metal that inducesnephrotoxicity through stimulating the oxidative stress inkidney cells. In this study, we investigated the protectiveeffects of hesperidin and eugenol on Cd-induced nephrotoxicityand their impact on modulating oxidative stress,Bax/Bcl2 ratio and cleaved caspase 3 level.Methods: Male Wistar rats were divided into: Normalgroup; Cd-treated group; hesperidin & Cd-treated groupand eugenol&Cd-treated group. Rats received CdCl2 (5 mg/kg body weight/daily) via oral gavage for four weeks toinduce kidney toxicity.Results: The results showed that, both hesperidin & Cdand eugenol & Cd- treated groups exhibited lower serumcreatinine and urea levels as well as better kidney tissueintegrity compared to the Cd-treated group. Moreover, theycould preserve the cellular antioxidants to normal levels aswas seen in a significantly lower malondialdehyde content,but significantly higher catalase and superoxide dismutaseactivities compared to the Cd-treated group. Furthermore,both groups significantly decreased the Cd-induced elevationin Bax/Bcl2 ratio and cleaved caspase 3 level.Conclusion: Administration of hesperidin or eugenoleffectively protected from the structural and functionalkidney damage induced by Cd exposure via antioxidantand anti-apoptotic effects.