Oleik asit ile oluşturulan akut akciğer hasarı modelinde likopenin etkileri

Abstract

Introduction: This study, we aimed to investigate the protective effect of lycopene in lung injury rat model.Materials and Methods: Twenty eight Wistar rats were enrolled into the study. Control group (n= 7) were applied PBS + et-hanol (9/1). A single dose of 100 mg/kg oleic acid (OA) intravenously was administrated to OA group (n= 7). One mL of cornoil was given daily to corn oil + OA group (n= 7) by gavage for five weeks. Lycopene was given by gavage to lycopene + OAgroup (n= 7) for five weeks. At the end of the 5thweeks, OA were given. Four hour after OA administration, lung tissue, blo-od samples were taken. Malondialdehyde, superoxide dismutase, glutathione-peroxidase, catalase levels were determined.Results: Malondialdehyde levels of serum, lung tissues were increased in OA, corn oil + OA groups than control, where asdecreased to controls levels in lycopene + OA group (p< 0.05). Superoxide dismutase, glutathione-peroxidase activities ofserum, tissue increased moderetaly or they were closed with control values. There was significant increase in lycopene +OA group values. Histopathological examination of control group was normal. OA, cornoil + OA groups had perivascular,alveolar edema, hemorrage, prominent neutrophil infiltration, destruction in alveolar structure. Lycopene + OA group hadless neutrophilic infiltration, perivascular, alveolar edema.Conclusion: Lycopene rich diet may have an important role preventing damages in lungs.