D-dimer seviyeleri ve COVID-19 şiddeti: Sistematik Derleme ve Metaanaliz

Özet

Giriş: Koronavirüs hastalığı 2019 (COVID-19), Aralık 2019’da Wuhan’da keşfedilen, çok sayıda asemptomatik vaka ve uzun bir kuluç-ka dönemi ile ölümcül ve pandemik bir hastalıktır. Araştırmacılar, yüksek D-dimer seviyelerinin hastalık şiddetini, akciğer komplikas-yonlarını ve tromboembolik olayları ortaya çıkmadan önce tahmin edebileceğini öne sürdü.Materyal ve Metod: PubMed, Scopus ve Web of Science’ta “D-dimer” ve “koronavirüs” veya “D-dimer” ve “COVID-19” anahtar kelimelerini kullanarak arama yaptık. Sürekli verilerin forest plot analizi ve COVID-19 enfeksiyonlu, şiddetli ve şiddetli olmayan has-talar arasındaki serum D-dimer konsantrasyonlarındaki farklılıkları değerlendirmek için Standart Ortalama Farklılıkları (SMD) kullan-dık. P değerini

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) is a fatal and pandemic disease discovered in December 2019 in Wuhan, with lots of asymptomatic cases and a long incubation period. The researchers suggested that high d-dimer levels could predict disease severity, lung complications, and throm-boembolic events before they occur. Materials and Methods: We searched in PubMed, Scopus, and Web of Science using the keywords “D-dimer” and “coronavirus” or “D-dimer” and “COVID-19.” We used Standardized Mean Differences (SMD) to build forest plots of continuous data and assess differences in serum D-dimer concentra-tions between severe and non-severe patients with COVID-19 disease. We evaluated p-value < 0.05 as statistically significant and preferred 95% confi-dence intervals (CIs).Results: The pooled results of all studies revealed that the D-dimer concentra-tions were significantly higher in patients with more severe COVID-19 (SMD: 2.32 μg/mL; 95% CI, 0.72 3.92 μg/mL, p< 0.001). We evaluated severe pati-ents with total D-dimer levels. D-dimer concentrations were significantly hig-her in severe patients against total COVID-19 patients (SMD: 2.01 μg/mL; 95% CI, 0.25 to 3.77 μg/mL, p= 0.08).Conclusion: We do not know the D-dimer increment mechanism in severe patients yet, but we think that these findings will be useful in the early diag-nosis of severe disease and the first treatment.